Two Cases of Veno-occlusive Disease/Sinusoidal Obstruction Syndrome After Thioguanine Treatment for Acute Lymphoblastic Leukemia
نویسندگان
چکیده
منابع مشابه
Gene expression and thioguanine nucleotide disposition in acute lymphoblastic leukemia after in vivo mercaptopurine treatment.
To elucidate interpatient variability in thioguanine nucleotide (TGN) concentrations in acute lymphoblastic leukemia (ALL) cells, we determined the TGN concentrations in leukemic blasts from 82 children with newly diagnosed ALL after intravenous administration of mercaptopurine (MP). Patients treated with MP alone achieved higher TGN concentrations than those treated with the combination of met...
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BACKGROUND The occurrence of Hepatic veno-occlusive disease (VOD) is rale liver disease. However, severe VOD is often lethal and one of the most common causes of death following stem cell transplantation (SCT). CASE REPORTS Case 1 was a 30-year-old woman who was diagnosed as Budd-Chiari syndrome with liver failure. She was admitted to our department to undergo liver transplantation. Four days...
متن کاملHepatic veno-occlusive disease (sinusoidal obstruction syndrome) after hematopoietic stem cell transplantation.
Hepatic veno-occlusive disease (VOD), increasingly referred to as sinusoidal obstruction syndrome, is a well-recognized complication of hematopoietic stem cell transplantation and contributes to considerable morbidity and mortality. In the Western Hemisphere, VOD, classified as a conditioning-related toxicity, is most commonly caused by stem cell transplantation. VOD has been described after al...
متن کاملSkeletal Manifestations of Acute Lymphoblastic Leukemia in Two Pediatric Cases
Pediatric leukemia is one of the most common pediatric malignancies, representing one quarter of all pediatric cancers. In the USA, the annual incidence is between 3.7 and 4.9 per 100,000 children aged 1-14 years, with peak incidence aged 2-5 years [1]. Both acute and chronic leukemia can present with a variety of symptoms and signs involving multiple systems in the body. Skeletal involvement i...
متن کاملMonitoring and treatment of acute kidney injury in children with acute lymphoblastic leukemia after high dose methotrexate chemotherapy
Abstact：objective To investigate acute kidney injury (AKI) in children with acute lymphoblastic leukemia (ALL) who received high dose methotrexate (MTX) chemotherapy and explore the corresponding treatment. Methods 180 children who received high dose MTX chemotherapy were observed with serum MTX concentration and serum creatinine. Patients with AKI of stage 3 or poor response to conventional tr...
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ژورنال
عنوان ژورنال: Journal of Pediatric Hematology/Oncology
سال: 2021
ISSN: 1077-4114
DOI: 10.1097/mph.0000000000002172